Tertiary lymphoid organs are associated with the progression of kidney damage and regulated by interleukin-17A

Background: Tertiary lymphoid organs (TLOs) occur after multiple chronic kidney injuries. interleukin-17A (IL-17A) has been reported to associate with the development of TLOs in inflammatory diseases. However, regulation renal and its clinical significance pathogenesis injury are unknown. Methods: To evaluate TLOs, we analyzed progression patients damage based on existence absence a larger multicenter cohort. We also blocked recruitment lymphocyte cells into by FTY720 (fingolimod) vivo. Besides, used aged IL-17A genetic knocked out mice IL-17A-neutralizing antibody explore role formation. Results: demonstrated that IgA nephropathy were associated disease severity independent risk factors for adjustment age, sex, mean arterial pressure, proteinuria and, baseline eGFR MEST-C score, especially early stage. Plasma levels TLO-related chemokines CXCL13, CCL19, CCL21 higher TLOs. Inhibiting formation could reduce intrarenal inflammation fibrosis, intervention was found be more effective. increased models, depletion or treatment anti-IL-17A resulted marked reduction as well alleviation fibrosis. Conclusion: These results indicate regulated may effective targets damage.