Telomerase activity in peripheral blood mononuclear cells after whole body irradiation
نویسندگان
چکیده
منابع مشابه
Telomerase activity in peripheral blood mononuclear cells after whole body irradiation.
Telomerase activity in vitro represents a radiation-inducible function. To test this effect after irradiation in vivo, we measured telomerase activity in peripheral blood mononuclear cells (PBMC) of 25 patients with leukemia or lymphoma before and 1 h after whole body irradiation. Telomerase activity of the patients was compared to telomerase activity in PBMC of 15 healthy volunteers. Periphera...
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Human telomerase is a specialized reverse transcriptase (hTERT) carrying its own RNA component (hTERC). This enables the enzyme to extend the leading strand of the long terminal telomere hexamer repeat sequences (TTAGGG) found on each chromosome. The telomeres are important for genomic stability by forming stable structures capping the end of the chromosomes. With few exceptions, adult normal-t...
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ژورنال
عنوان ژورنال: Oncology Reports
سال: 2007
ISSN: 1021-335X,1791-2431
DOI: 10.3892/or.17.4.865