منابع مشابه
Targeting the tumor niche to treat cancer.
Sattva S. Neelapu and Padmanee Sharma Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; and Department of Immunology...
متن کاملS02-05 Targeting tumor suppressor pathways to treat cancer
tion organelle. Primary cilia, immotile organelles found on most cells, have been implicated in several signaling pathways and we have observed direct binding of Hh protein to them. We find that the Ptc receptor protein is localized in cilia, where it prevents the accumulation of the Smo seven-transmembrane domain protein. Binding of Hh to Ptc causes departure of both from the cilium, allowing ...
متن کاملTargeting psychoemotional stress to treat prostate cancer.
E arlier epidemiological studies identified diet as a primary environmental factor that determines substantial differences in prostate cancer incidence and mortality between East Asian and West European societies. New data from experiments performed in tissue culture and with animal models as well as epidemiological studies suggest that psychoemotional stress could be a second environmental com...
متن کاملTargeting Both Tumor and Stroma Cells to Treat Melanoma: NIPAWILMA.
All patients enrolled in either phase I or phase II will be treated according to the following treatment plan: Week 1–24: Chemotherapy with paclitaxel combined with nintedanib/placebo Week 25–48: Extended monotherapy with nintedanib/placebo Week 52 (or approximately 4 weeks after last treatment dose): End-of-treatment visit. Follow up: After end of treatment the survival, disease status and fur...
متن کاملTargeting the hypoxia pathway to treat pancreatic cancer
The correlation between hypoxia and pancreatic cancer has long been discussed. Hao's research team made many efforts on revealing the oncogenic function of hypoxic inducible factor-1 (HIF-1) in pancreatic cancer progression and development in recent years. Based on their research, they linked micro-environmental regulation of pancreatic cancer and its clinical significance. Hao's research team ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2015
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1517389112