T-Type Calcium Current in Sickle Cell Disease
نویسندگان
چکیده
منابع مشابه
T-type calcium current in sickle cell disease: a channel to therapy?
In 1910, James Herrick made the first report of a case of sickle cell anemia.1 He described thin, elongated, sickleshaped, and crescent-shaped red blood corpuscles. Soon afterward, the observation of sickle cells in the asymptomatic father of a sickle cell anemia patient raised the possibility of an inherited disorder.2 The distinction between symptomatic sickle cell anemia and the asymptomatic...
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Sickle cell disease (SCD) is one of the most common monogenic diseases worldwide. Although there have been some advances in the management of SCD, much remains to be learned about the mechanisms underlying the wide phenotypic diversity of the disease. In resource poor countries, basic facilities for diagnosis and management are lacking, systematic screening is not common practice, and diagnosis...
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H omozygous sickle cell disease (SCD) is an auto-somal recessive genetic disease that results from the substitution of valine for glutamic acid at position 6 of the β-globin gene, leading to production of a defective form of hemoglobin, hemoglo-bin S (HbS). The prevalence of SCD is about 1-2% among African descendants in Europe and the United States and 4% or higher in West Africa. SCD shows br...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2003
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000089472.85758.8b