Systemic therapy‐based split‐course stereotactic body radiation therapy

Purpose Given the therapeutic toxicity of concurrent chemoradiotherapy, dose chemotherapy is always limited. Hence, question how to administer adequate synchronize stereotactic body radiation therapy (SBRT) treatment strategy for maximizing benefits neoadjuvant improve prognosis a challenging and debatable issue. Methods We summarized major clinical trials preclinical studies split-course CRT SBRT explored feasibility theoretical advantages implementing systemic simultaneously. Results Split-course radiotherapy mainly proposed with aim further reducing improving patient's tolerance, added features extended interval between fractions instead daily irradiation. In past, was not recommended in terms local tumor control rates, late response survival without significant improvement relative continuous radiotherapy. has different biological effects compared conventional (CRT). The current findings suggest that model good tolerance facilitates implementation adaptive Conclusion This upgrading doses combination therapy, especially vascular targeting agents immunotherapy, thus avoiding disadvantages CRT, such as reduced rate, increased time economic cost, potential achieve better suppression.