Synthesis of biologically active compounds using photochemical pericyclic reactions.

Synthesis of Some Nitrogen Functional Derivatives of 5-substituted-6-azauracil as Biologically Active Compounds

3-Arylhydrazono-2,4-dioxo-4-phenylbutanoates have been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides. Reactions of the 3-arylhydrazono-2,4- dioxo-4-phenylbutanoates with 1-aminoguanidine, semicarbazide, and thiosemicarbazide gave 5-substituted 2-imino-6-azauracil (3a), 6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds ...

Novel synthesis of biologically active nitro heterocyclic compounds

Introduction A vast number of heterocyclic moieties are used in pharmaceutical research, agricultural science and drug discovery. Heterocyclic building blocks also have practical use as components in dyestuffs, antioxidants, copolymers, bases and ligands. Nitro heterocyclic compounds have diverse biological activity, antiinflammatory or vasodilator activity and structure activity relationship, ...

Stereocontrolled synthesis of carbocycles via four successive pericyclic reactions.

Herein, we report a highly diastereoselective construction of fused carbocycles using four successive pericyclic reactions.

synthesis of some nitrogen functional derivatives of 5-substituted-6-azauracil as biologically active compounds

Synthesis of Biologically Active -Aminophosphonates

Abstract: Highly convergent Synthesis of -aminophosphonates were most conveniently achieved using organophosphorus chemistry. Synthesis of -aminophosphonates were accomplished by three-component coupling of carbonyl, amine and hydrophosphoryl compounds. These aminophosphonates exhibited promising antimicrobial, antioxidant and anticancer activity. Some recent developments and applications to th...