Synthesis of 2-Amino-3-benzyl-5-(p-hydroxyphenyl)pyrazine.
نویسندگان
چکیده
منابع مشابه
Synthesis of 2-amino-3-benzyl-5-(p-hydroxyphenyl)pyrazine.
2-Amino-3-benzyl-5-(p-hydroxyphenyl)pyrazine (2), a precursor of Watasenia preluciferin (coelenterazine) (1), is widely distributed in marine bioluminescent animals. It was prepared from p-hydroxyphenylglyoxal aldoxime (5) in two steps; by condensation with or-aminophenylpropiononitrile in the presence of TiCl4 in pyridine, followed by reduction of the resulting N-oxide (6) with Zn-AcOH in CH2C...
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The o-nitrophenyl group at position 4 of dihydropyridine of nifedipine analogues was replaced with 2-alkylthio-1-benzyl-5-imidazolyl substituent. Starting from dihydroxyacetone 2-alkythio-1-benzyl- 5-formyl imidazole (3) was first synthesized which was subsequently used in synthesizing symmetrical (5a-f) and asymmetrical (6a,b) dihydropyridines. Primarily pharmacological studies of the title co...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2002
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.50.301