SYNTHESIS, CHARACTERIZATION AND BIOCOMPATIBILITY OF PLANT-OIL BASED HYDROGELS

Biocompatible hydrogels are used in a variety of biomedical applications, including tissue scaffolds, drug delivery systems, lab/organ-on-a-chips, biosensors, cell-culture studies and contact lenses. The demand for novel functional monomers to be hydrogel synthesis is increasing as the number applications need biomaterials increase. purpose study was develop from renewable materials. Acrylated methyl ricinoleate, plant oil-based monomer, material. effects acrylated ricinoleate/N-isopropyl acrylamide molar ratio on structural properties, thermal stability vitro cytotoxicity were studied. FTIR spectroscopy characterize properties hydrogels, while TGA properties. HEK293 Cos-7 cell lines test hydrogels. IC50 values ricinoleate N-isopropyl found greater than 25 mg/mL. Cell viability containing 50% or more 60%, biocompatibility decreased with decreasing ricinoleate. Cells showed minimum 80% when incubated degradation products. An environmentally friendly method developed biocompatible materials produced applications.