Synergistic resistance mechanisms in Pseudomonas aeruginosa
نویسندگان
چکیده
منابع مشابه
Mechanisms of antibiotic resistance in Pseudomonas aeruginosa.
Pseudomonas aeruginosa is a notoriously difficult organism to control with antibiotics or disinfectants1. Recent reports on the antibiotic sensitivity patterns of P. aeruginosa in the UK have highlighted the problem of antibiotic resistance in cystic fibrosis (CF) strains in comparison with other hospital isolates2,3. Table 1 summarizes the current position in which the resistance rates of P. a...
متن کاملCarbapenem resistance mechanisms in Pseudomonas aeruginosa clinical isolates.
In order to define the contributions of the mechanisms for carbapenem resistance in clinical strains of Pseudomonas aeruginosa, we investigated the presence of OprD, the expressions of the MexAB-OprM and MexEF-OprN systems, and the production of the beta-lactamases for 44 clinical strains. All of the carbapenem-resistant isolates showed the loss of or decreased levels of OprD. Three strains ove...
متن کاملExtracellular DNA-induced antimicrobial peptide resistance mechanisms in Pseudomonas aeruginosa
Extracellular DNA (eDNA) is in the environment, bodily fluids, in the matrix of biofilms, and accumulates at infection sites. eDNA can function as a nutrient source, a universal biofilm matrix component, and an innate immune effector in eDNA traps. In biofilms, eDNA is required for attachment, aggregation, and stabilization of microcolonies. We have recently shown that eDNA can sequester divale...
متن کاملMechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa.
Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance determinants. Foremost among the mechanisms of resistance in both of these pathogens is the production of beta -lactamases and aminoglycoside-modifying enzymes. Additionally, diminished expression of outer membrane proteins, mutation...
متن کاملAntibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment.
Pseudomonas aeruginosa continues to be a major cause of infections in Western society, in part because of its high intrinsic resistance to antibiotics. It has been demonstrated that this intrinsic resistance arises from the combination of unusually restricted outer-membrane permeability and secondary resistance mechanisms such as energy-dependent multidrug efflux and chromosomally encoded perip...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1987
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/19.4.413