Structure, Function, and Pharmacology of NMDA Receptor Channels
نویسندگان
چکیده
منابع مشابه
Structure, function, and pharmacology of NMDA receptor channels.
NMDA receptors have received much attention over the last few decades, due to their role in many types of neural plasticity on the one hand, and their involvement in excitotoxicity on the other hand. There is great interest in developing clinically relevant NMDA receptor antagonists that would block excitotoxic NMDA receptor activation, without interfering with NMDA receptor function needed for...
متن کاملNMDA receptor subunits: function and pharmacology.
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed in the central nervous system that play key roles in excitatory synaptic transmission. Because of their involvement in numerous neurological disorders, NMDARs are also targets of therapeutic interest. NMDARs occur as multiple subtypes which differ in their subunit composition and in their biophysical and p...
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Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synaptic transmission in the central nervous system. Based on their structural and pharmacological properties, ionotropic glutamate receptors can be divided into three groups, which include α-amino-3-hydroxy-5-methyl-4-isoxasolepropionic acid (AMPA) receptors, kainate receptors, and N-methyl-D-aspartate (NMDA) ...
متن کاملInternational Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.
Howard Hughes Medical Institute, Children’s Hospital, Boston, Massachusetts (D.E.C.); Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California (D.J.); Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore Maryland (C.M.); and Institut für Pharmakologie, Charité–Universitätsmedizin Berlin, Campus Benjamin Fran...
متن کامل[Structure and function of NMDA-type glutamate receptor subunits].
INTRODUCTION To review the physiology of the glutamate receptor subunits such as N-methyl-D-aspartate (NMDA). DEVELOPMENT Glutamic acid (Glu) is the major excitatory neurotransmitter in the central nervous system which interacts with two types classified into two types: metabotropic and ionotropic. Ionotropic receptors are classified according to the affinity of their specific agonists: N-met...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2014
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.932678