Structure-Based Discovery of a Novel, Noncovalent Inhibitor of AmpC β-Lactamase

Structure-Based Discovery of a Novel, Noncovalent Inhibitor of AmpC -Lactamase

to be developed. -lactamases are the most widespread resistance Several classes of non-lactam inhibitors of -lactamechanisms to -lactam antibiotics, and there is a mases have been identified. Transition-state analog inpressing need for novel, non-lactam drugs. A datahibitors (Figure 1C), such as boronic acids and phosphobase of over 200,000 compounds was docked to the nates, inhibit both class ...

The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β-lactamase in Enterobacter cloacae

Induction of ampC β-lactamase expression can often compromise antibiotic treatment and is triggered by several β-lactams (such as cefoxitin and imipenem) and by the β-lactamase inhibitor clavulanic acid. The novel β-lactamase inhibitor avibactam (NXL104) is a potent inhibitor of both class A and class C enzymes. The potential of avibactam for induction of ampC expression in Enterobacter cloacae...

AmpC β lactamases in Urinary Klebsiella pneumoniae Isolates: First Report of ACC Type AmpC β-lactamase Resistance in Iran

Background & Objective: The production of plasmid-mediated AmpC beta-lactamases (PMABLs) among urinary Klebsiella pneumoniae isolates causes a severe problem to the successful treatment of urinary tract infections (UTIs). This study was designed to evaluate antimicrobial resistance, the presence of AmpC beta-lactamase genes, and the genetic relatedness among K. pneumoniae strains separated from...

Characterization of a novel AmpC β-lactamase produced by a carbapenem-resistant Cedecea davisae clinical isolate.

A Cedecea davisae isolate, which was intermediate or resistant to third-generation cephalosporins and carbapenems, was recovered from a urine sample. Susceptibility testing, isoelectric focusing, and analysis of outer membrane proteins showed that AmpC β-lactamase expression combined with porin deficiency accounted for the carbapenem resistance. A cloning experiment followed by phenotypic and e...

AAI101, a Novel β-Lactamase Inhibitor: Microbiological and Enzymatic Profiling