Stochastic threshold in cell size control
نویسندگان
چکیده
Classic models of cell size control consider that cells divide when reaching a threshold, e.g., size, age, or extension. The molecular basis the threshold involves multiple layers regulation as well gene noise. In this paper, we study cycle first-passage problem with stochastic and discover such stochasticity affects intergeneration statistics, which bewilders criteria to distinguish types models. analytic results show autocorrelation in can drive sizer model adderlike even timerlike is supported by simulations. Following picture propagate further adder be driven one positively autocorrelated sizerlike negatively autocorrelated. This work highlights importance examining noise control.
منابع مشابه
Stochastic Modeling of Bacterial Cell Size Control and Homeostasis
Recent studies have revealed the rules controlling cell size homeostasis in bacteria. However, whether these mechanisms apply to growth-defective backgrounds remains an open question. Herein, we propose a Markov chain model describing bacterial growth in wt or growth-defective backgrounds and test some of our predictions experimentally. Our results suggest that, in mutant backgrounds, bacteria ...
متن کاملEffect of Cell Size and Shape on Electric Field Threshold and Critical Transmembrane Voltage for Electroporation
Introduction: Electroporation is a technique for increasing the permeability of the cell membrane to otherwise non-permeate molecules due to an external electric field. This permeability enhancement is detectable if the induced transmembrane voltage becomes greater than a critical value which depends on the pulse strength threshold. In this study, the variabil...
متن کاملGovernment Size Threshold and Economic Growth in Iran
We apply the two-sector production function developed by Ram (1986) to estimate the threshold regression model for Iran, concerning the effect of government size on economic growth. Three government size indicators are used to find out the different threshold points. The results show a non-linear relationship of the Armey curve in Iran, in which the threshold effects corresponding to total gove...
متن کاملSize sensors in bacteria, cell cycle control, and size control
Bacteria proliferate by repetitive cycles of cellular growth and division. The progression into the cell cycle is admitted to be under the control of cell size. However, the molecular basis of this regulation is still unclear. Here I will discuss which mechanisms could allow coupling growth and division by sensing size and transmitting this information to the division machinery. Size sensors co...
متن کاملCell Size Control in Yeast
Cell size is an important adaptive trait that influences nearly all aspects of cellular physiology. Despite extensive characterization of the cell-cycle regulatory network, the molecular mechanisms coupling cell growth to division, and thereby controlling cell size, have remained elusive. Recent work in yeast has reinvigorated the size control field and suggested provocative mechanisms for the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Physical review research
سال: 2023
ISSN: ['2643-1564']
DOI: https://doi.org/10.1103/physrevresearch.5.013173