Stereoselective total synthesis of the potent anti-asthmatic compound CMI-977 (LDP-977)
نویسندگان
چکیده
منابع مشابه
Dmd063552 977..983
Esculetin (6,7-dihydroxycoumarin, ET) and 4-methylesculetin (6,7dihydroxy-4-methylcoumarin, 4-ME) are typical coumarin derivatives that are attracting considerable attention because of their wide spectrum of biologic activities, but their metabolism remains unknown. This study aimed to elucidate the in vitro UDPglucuronosyltransferase (UGT) metabolism characteristics of ET and 4-ME. 7-O-monoglu...
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Ethambutol (EMB), an effective first-line antituberculosis agent, can cause serious visual impairment or irreversible vision loss in a significant number of patients. However, the mechanism underlying this ocular cytotoxicity remains to be elucidated. In this study, we found that there were statistically significant doseand timedependent increases in the number of cytoplasmic vacuoles and the l...
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We report observations of the J = (1–0) CO molecular emission line toward the L977 molecular cloud. To study the correlation between CO emission and dust extinction we constructed a Gaussian smoothed map of the infrared extinction measured by Alves et al. (1998) at the same angular resolution (50) as our molecular–line observations. This enabled a direct comparison of CO integrated intensities ...
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Introduction. – The 6-substituted 5,6-dihydro-2H-pyran-2-one A, an a,b-unsaturated d-lactone, is an important structural subunit in many biologically promising natural products. This unit is of interest for a wide variety of biological activities, such as insect-growth inhibitors and insect antifeedent, cytotoxic activities, and antifungal and antitumor properties [1]. The pyran units are widel...
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The multiphonon energy exchange between a neutral He atom and a stepped Ni~977! surface has been measured in order to examine how the presence of a regular array of atomic-scale steps on a surface modifies energy exchange in the classical multiphonon scattering regime. At elevated substrate temperatures, we compare the multiphonon scattering with the predictions of a classical theory that has p...
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2013
ISSN: 0103-5053
DOI: 10.1590/s0103-50532013000200003