Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells
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چکیده
منابع مشابه
Pazopanib and HDAC inhibitors interact to kill sarcoma cells.
The present studies were to determine whether the multi-kinase inhibitor pazopanib interacted with histone deacetylase inhibitors (HDACI: valproate, vorinostat) to kill sarcoma cells. In multiple sarcoma cell lines, at clinically achievable doses, pazopanib and HDACI interacted in an additive to greater than additive fashion to cause tumor cell death. The drug combination increased the numbers ...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2012
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.19771