Solvent-Controlled Selective Transformation of 2-Bromomethyl-2-methylaziridines to Functionalized Aziridines and Azetidines
نویسندگان
چکیده
منابع مشابه
A general, enantioselective synthesis of N-alkyl terminal aziridines and C2-functionalized azetidines via organocatalysis.
A short, high-yielding protocol involving the enantioselective α-chlorination of aldehydes has been developed for the enantioselective synthesis of C2-functionalized aziridines and N-alkyl terminal azetidines from a common intermediate. This methodology allows for the rapid preparation of functionalized aziridines in 50-73% overall yields and 88-94% ee, and azetidines in 22-32% overall yields a...
متن کاملRegio- and stereocontrolled synthesis of novel 3-sulfonamido-2,3,4,5-tetrahydro-1,5-benzothiazepines from 2-(bromomethyl)- or 2-(sulfonyloxymethyl)aziridines.
2-(Bromomethyl)-1-sulfonylaziridines were converted into novel 3-sulfonamido-2,3,4,5-tetrahydro-1,5-benzothiazepines upon treatment with 2-aminothiophenol in THF in the presence of K2CO3. Starting from 3-substituted 2-(sulfonyloxymethyl)aziridines, a regio- and stereocontrolled synthesis of trans-2-phenyl- and trans-4-(phenyl or propyl)-3-sulfonamido-2,3,4,5-tetrahydro-1,5-benzothiazepines was ...
متن کاملPreparation of Racemic and Optically Active Trifluoromethyl Aziridines and Azetidines
Recent advances regarding the synthetic chemistry of fluorinated aziridines and azetidines are presented in this chapter. These small heterocycles are of high importance both as building blocks for more complex structures and as active parts of medicinal chemistry-oriented compounds. Methods are presented according to the precursors used for the synthesis.
متن کاملcompactifications and representations of transformation semigroups
this thesis deals essentially (but not from all aspects) with the extension of the notion of semigroup compactification and the construction of a general theory of semitopological nonaffine (affine) transformation semigroup compactifications. it determines those compactification which are universal with respect to some algebric or topological properties. as an application of the theory, it is i...
15 صفحه اولFacile construction of highly functionalized 2-pyrrolines via FeCl(3)-catalyzed reaction of aziridines with arylalkynes.
A series of highly functionalized 2-pyrrolines have been constructed by using a novel FeCl(3)-catalyzed reaction of aziridines with arylalkynes, in which an aryl-substituted alkenyl cation is involved.
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2012
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo202637a