Soluble Klotho and Brain Atrophy in Alcoholism
نویسندگان
چکیده
منابع مشابه
Brain atrophy and alcoholism.
Alcoholism has no satisfactory definition, yet no more useful term is available to describe chronic and deleterious over-consumption. Alcohol is mostly drunk for its pharmacological effects on the nervous system, so not surprisingly the brain is one of the organs that suffers most-along with the liver, which detoxifies the alcohol. The effects on the nervous system include direct intoxication, ...
متن کاملBrain Signals and Alcoholism
Electroencephalogram (EEG) is the recording of electrical activity through various electrode sensors placed on the scalp. The electrical signal is recorded as waves that can be classified as normal or abnormal. Different types of normal waves can indicate various states or activity levels of the functioning of the brain. Abnormal electricity of the brain may represent many brain disorders, whic...
متن کاملEstablishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects.
BACKGROUND Alpha-Klotho (alphaKl) regulates mineral metabolism such as calcium ion (Ca(2+)) and inorganic phosphate (Pi) in circulation. Defects in mice result in clinical features resembling disorders found in human aging. Although the importance of transmembrane-type alphaKl has been demonstrated, less is known regarding the physiological importance of soluble-type alphaKl (salphaKl) in circu...
متن کاملExcessively high soluble Klotho in patients with acromegaly.
OBJECTIVES Klotho-deficient mice develop a syndrome resembling accelerated ageing, and genetic variants of Klotho have been associated with human ageing. In humans, serum levels of soluble Klotho decrease with age and with chronic renal failure. The aim of our study was to examine the relationship between excess growth hormone (GH) and serum levels of Klotho in patients with acromegaly, a disea...
متن کاملSoluble α-Klotho serum levels in Chronic Kidney Disease (CKD)
Transmembrane α-Klotho (TM-Klotho), mainly expressed in renal distal tubules, is a co-factor for FGF23 receptor. Circulating soluble α-Klotho (s-Klotho) results from shedding of the ecto-domain of TM-Klotho and has specific effects on urinary Phosphate (P) and Calcium (Ca) transport. The possibility exists that a decrease in TM-Klotho, described in experimental chronic kidney disease (CKD), may...
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ژورنال
عنوان ژورنال: Alcohol and Alcoholism
سال: 2018
ISSN: 0735-0414,1464-3502
DOI: 10.1093/alcalc/agy037