SnapShot: Non-Small Cell Lung Cancer

SnapShot: non-small cell lung cancer.

MEK MEK162 GDC-0973 GSK1120212 MSC1936369B STAT3 OPB51602 AKT MK2206 Stage a Est. % General treatment recommendations 5-year overall survival b clinical stage path. stage IA 14% Surgical resection 50% 73% IB 10% Surgical resection, can consider adjuvant chemotherapy in selected cases (e.g. tumor size > 4cm) 43% 58% IIA 6% Surgical resection followed by adjuvant chemotherapy 36% 46% IIB 5% Surgi...

Sentinel Node Mapping in Non-small Cell Lung Cancer Using an Intraoperative Radiotracer Technique

 Objective(s): Lymph node metastases are the most significant prognostic factor in localized non-small cell lung cancer (NSCLC). Identification of the first nodal drainage site (sentinel node) may improve detection of metastatic nodes. Extended surgeries, such as lobectomy or pneumonectomy with lymph node dissection, are among the therapeutic options of higher acceptab...

Clinicopathological Features of Patients with Non-small-cell Lung Cancer in West of Iran

Background: Lung cancer is the most common cause of cancer death worldwide with an annual mortality rate of more than 1.3 million worldwide. We aimed to analyze the clinicopathological features of patients with non-small-cell lung cancer (NSCLC) in west of Iran. Methods: 64 patients with NSCLC who referred to our clinic were analyzed. Sex, age, histopathology, location of the tumor, treatment,...

ATM induces radioresistance of non-small cell lung cancer A549 cells by downregulation of MDMX

Background: Tumor radioresistance leads to a reduction in the efficiency of radiation therapy. It is very important to explore the cellular mechanisms leading to radioresistance and to find potential therapeutic targets, which might improve the efficacy of radiation therapy. This study was to investigate the role of ataxia-telangiectasia mutated (ATM) and murine double minute X (MDMX) in radior...

Non-Small Cell Lung Cancer