Small fibre neuropathy, fibromyalgia and dorsal root ganglia sodium channels
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منابع مشابه
Small fibre neuropathy, fibromyalgia and dorsal root ganglia sodium channels.
Sir, In their elegant study, Üçeyler et al. (2013) provide objective evidence of small fibre neuropathy in patients with fibromyalgia. They conclude that fibromyalgia may be a neuropathic pain syndrome (Üçeyler et al., 2013). Small fibre neuropathy is a disorder of the peripheral nerves resulting in sensory changes and sympathetic dysfunction. For years, we have proposed that fibromyalgia is a ...
متن کاملReply: Small fibre neuropathy, fibromyalgia and dorsal root ganglia sodium channels.
Sir, We read with great interest the letter by Dr. Martinez-Lavin in response to our article (Üçeyler et al., 2013). Sympathetic dysfunction has indeed been widely discussed in fibromyalgia syndrome. During a systematic review of the literature undertaken in 2008 for the first German S3-guideline on fibromyalgia syndrome we already identified 29 original articles on this subject, including work...
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BACKGROUND A consistent line of investigation suggests that autonomic nervous system dysfunction may explain the multi-system features of fibromyalgia (FM); and that FM is a sympathetically maintained neuropathic pain syndrome. Dorsal root ganglia (DRG) are key sympathetic-nociceptive short-circuit sites. Sodium channels located in DRG (particularly Nav1.7) act as molecular gatekeepers for pain...
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ژورنال
عنوان ژورنال: Brain
سال: 2013
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/awt114