Single pass tangential flow filtration: Critical operational variables, fouling, and main current applications

• Need for intensified processes in biopharmaceutics increased interest SPTFF. SPTFF has advantages compared to TFF e.g. easier operate and monitor. The use of cellulose or polysulfone membranes is critical, depends on application. Cleaning cost can be higher than operation cost, so a good fouling plan needed. This mini-review reviews applications SPTFF, particularly bioprocessing. biopharmaceutical industry an ongoing improving manufacturing efficiency productivity while at the same time reducing costs by developing intensified, linked continuous processes. In recent years, upstream bioprocesses improved significantly resulting volumes titers, which have put downstream under enormous pressure. Single Pass Tangential Flow Filtration (SPTFF) technology that offers opportunity reduce process efficiently through inline concentration one single pass series without need retentate recirculation. links operations capability ensure production. review seeks investigate both early papers developments field, including single-use 3D printed membrane modules. To our knowledge, this first address aimed gathering all relevant information about topic, with special focus application bioprocessing from evolved. Due growing processes, within increasing, hence importance topic review. starts thorough comparison between normal tangential flow filtration (TFF) principles, configuration, typical features these technologies. Also addressed are design equations how tackle fouling. ends providing main as well future perspectives operation. mainly deals but includes examples food wastewater treatment.