Single-dose depot leuprolide is as efficient as daily short-acting leuprolide in ICSI cycles
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چکیده
منابع مشابه
CLINICAL PHARMACOLOGY Leuprolide acetate is a long-acting GnRH analog. A single monthly injection of LUPRON
The front chamber of LUPRON DEPOT 3.75 mg prefilled dual-chamber syringe contains leuprolide acetate (3.75 mg), purified gelatin (0.65 mg), DL-lactic and glycolic acids copolymer (33.1 mg), and D-mannitol (6.6 mg). The second chamber of diluent contains carboxymethylcellulose sodium (5 mg), D-mannitol (50 mg), polysorbate 80 (1 mg), water for injection, USP, and glacial acetic acid, USP to cont...
متن کاملHalf-dose, long-acting gonadotropin-releasing hormone agonist (Diphereline) is comparable with daily injections of short-acting gonadotropin-releasing hormone agonist (Suprefact) in IVF/ICSI cycles
INTRODUCTION The aim of the study was to compare the efficacy of half-dose, long-acting GnRH analogue (Diphereline) with Suprefact in IVF/ICSI (in vitro fertilization/intracytoplasmic sperm injection) cycles. MATERIAL AND METHODS In this randomized clinical trial performed in Royan Institute, 126 infertile women who were first time candidates for IVF/ICSI were enrolled. Patients were randomly...
متن کاملLUPRON DEPOT® -3 Month 11.25 mg (leuprolide acetate for depot suspension) 3-MONTH FORMULATION
Leuprolide acetate is a long-acting GnRH analog. A single injection of LUPRON DEPOT–3 Month 11.25 mg will result in an initial stimulation followed by a prolonged suppression of pituitary gonadotropins. Repeated dosing at quarterly (LUPRON DEPOT–3 Month 11.25 mg) intervals results in decreased secretion of gonadal steroids; consequently, tissues and functions that depend on gonadal steroids for...
متن کاملTherapeutic Review Leuprolide Acetate
Leuprolide acetate is a potent Gonadotropin Releasing Hormone (GnRH) agonist. The general premise behind leuprolide is that it inhibits the synthesis of lutenizing hormone and follicle stimulating hormone via a negative feedback. By reducing the production of these hormones, the drug effectively reduces estrogen and androgen production. This compound has been formulated as a depot formulation (...
متن کاملSerum luteinizing hormone rises within minutes after depot leuprolide injection: implications for monitoring therapy.
OBJECTIVE To find the time of the serum gonadotropin peak after depot leuprolide injection in children and to show that depot leuprolide therapy can be monitored by measuring serum luteinizing hormone (LH) immediately after injections. STUDY DESIGN We measured concentrations of leuprolide, LH, and follicle-stimulating hormone (FSH) at multiple time points before and after the first dose of de...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2007
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/dem054