Serini Reaction of 5a-Cholestane-3/3, 5, 6a-triol 3, 6-diacetate
نویسندگان
چکیده
منابع مشابه
Metabolism of steroids: The isolation of cholestane-3:5:6-triol and other substances from ox liver extracts.
IN Part 1 [Haslewood, 1939], the isolation from ox liver of oc-7-hydroxycholesterol was reported. Since that time, a '/3-7-hydroxycholesterol' has been mentioned as isolated from hog liver [MacPhillamy, 1940], and /3-7-hydroxycholesterol has been obtained from pregnant mares' serum [Wintersteiner & Ritzmann, 1940]. Wintersteiner & Bergstrom [1941] report further that cholesterol can be converte...
متن کامل6-Hydroxyimino-5α-cholestane
The title compound, C(27)H(47)NO, is a steroid derivative composed of a saturated carbon fused-ring framework with an alkyl side chain. Ring bond lengths have normal values with an average of 1.533 (2) Å, while the cholestane side chain shows an average bond length of 1.533 (2) Å. The three cyclohexane rings adopt chair conformations or close to chair conformations while the cyclopentane ring i...
متن کاملCholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation.
The mutagenicity of oxysterols, cholesterol-3beta,5alpha,6beta-triol (alpha-Triol), 7-keto-cholesterol (7-Keto) and cholesterol-5alpha,6alpha-epoxide (alpha-Epox) were examined by the Ames method and chromosome aberration test in this study. Only alpha-Triol concentration-dependently caused an increase of bacterial revertants in the absence of metabolic activating enzymes (S9), but not 7-keto a...
متن کاملThe Role of Matrix Metalloproteinase-3 Functional 5A/6A Promoter Polymorphism in Tumor Cell Progression and Metastasis of Breast Cancer
In the human genome, chromosome 11 contains a cluster of matrix metalloproteinase (MMP) genes. Single nucleotide polymorphisms in the promoter region of MMP genes are important for MMP expression. A common adenine deletion polymorphism (5A) at position -1171 of the MMP-3 gene promoter (5´-AAAAAACCAT-3´ change to 5´-AAAAACCAT-3´) facilitates transcriptional factor binding and MMP-3 promoter acti...
متن کاملThe 5A/6A polymorphism of the matrix metalloproteinase 3 gene promoter and breast cancer.
PURPOSE The matrix metalloproteinase 3 (MMP3), also known as stromelysin-I, is a key-player for carcinogenesis and tumor growth. A 5A/6A promoter polymorphism is associated with differences in MMP3 activity and has been linked to cancer susceptibility in some studies. In the present study we evaluated the role of this polymorphism for breast cancer risk. EXPERIMENTAL DESIGN A case-control stu...
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ژورنال
عنوان ژورنال: Nippon kagaku zassi
سال: 1962
ISSN: 0369-5387,2185-0917
DOI: 10.1246/nikkashi1948.83.11_1236