Sequence signals which may be required for efficient formation of mRNA 3' termini
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چکیده
منابع مشابه
Sequence signals which may be required for efficient formation of mRNA 3' termini.
It has been known for sometime that AATAAA (Proudfoot and Brownlee, 1976) is often required for 3' mRNA processing. More recently, McLauchlan et al. (1985) have shown the high incidence of YGTGTTYY (Y is a pyrimidine) downstream from the poly (A) addition site. Our results fully support their findings. There have been indications that additional sequences are required either for transcription t...
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Formation of the 3' termini of mRNAs in animal cells involves endonucleolytic cleavage of a pre-mRNA, followed by polyadenylation of the newly formed end. Here we demonstrate that, during cleavage in vitro, the highly conserved AAUAAA sequence of the pre-mRNA forms a complex with a factor present in a crude nuclear extract. This complex is required for cleavage and polyadenylation. It normally ...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1986
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/14.8.3557