منابع مشابه
Secretory group II phospholipase A(2) : a newly recognized acute-phase reactant with a role in atherogenesis.
There is compelling evidence that atherosclerosis is an inflammatory disease.1 Increased levels of markers of systemic inflammation, such as the acute-phase reactant C-reactive protein, have been associated with acute coronary events in patients with atherosclerosis.2 The secretory group II phospholipase A2 (sPLA2) recently has been added to the group of acute-phase reactants,3 and its plasma l...
متن کاملSecretory type II phospholipase A binds to ischemic myocardium
Objective: An increase of circulating secretory Phospholipase A (sPLA ) is a risk factor for coronary artery disease. We hypothesized 2 2 that this reflects participation of sPLA in local inflammatory reactions ensuing in ischemic myocardium. Therefore, we studied the course 2 of circulating sPLA , in patients with acute myocardial infarction (AMI) or unstable angina pectoris (UAP), and investi...
متن کاملGroup X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism.
Group X secretory phospholipase A2 (GX sPLA2) potently hydrolyzes membrane phospholipids to release arachidonic acid (AA). While AA is an activator of glucose-stimulated insulin secretion (GSIS), its metabolite prostaglandin E2 (PGE2) is a known inhibitor. In this study, we determined that GX sPLA2 is expressed in insulin-producing cells of mouse pancreatic islets and investigated its role in b...
متن کاملRole of group II secretory phospholipase A2 in atherosclerosis: 2. Potential involvement of biologically active oxidized phospholipids.
Secretory nonpancreatic phospholipase A2 (group II sPLA2) is induced in inflammation and present in atherosclerotic lesions. In an accompanying publication we demonstrate that transgenic mice expressing group II sPLA2 developed severe atherosclerosis. The current study was undertaken to determine whether 1 mechanism by which group II sPLA2 might contribute to the progression of inflammation and...
متن کاملComparison of the properties of human group II phospholipase A2 with other secretory phospholipases.
The human group II secretory phospholipase A, (sPLA,) has been implicated in a number of inflammatory conditions, including rheumatoid arthritis. A continuous fluorescence displacement assay which measures the release of long chain fatty acids [l] has been used to investigate the activity of a recombinant form of this human enzyme (HR PLAJ and is reported here for the first time. Secretory phos...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2000
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.86.6.610