Secreted Immunomodulatory Viral Proteins as Novel Biotherapeutics

Secreted Immunomodulatory Viral Proteins

A new insight into viral proteins as Immunomodulatory therapeutic agents. KSHV vOX2 a homolog of human CD200 as a potent anti-inflammatory protein

The physiologic function of the immune system is defense against infectious microbes and internal tumour cells, Therefore, need to have precise modulatory mechanisms to maintain the body homeostasis. The mammalian cellular CD200 (OX2)/CD200R interaction is one of such modulatory mechanisms in which myeloid and lymphoid cells are regulated. CD200 and CD200R molecules are membrane proteins that t...

Secreted trimeric viral envelope proteins as a tool for new vaccine design and biochemical assays

properties of these proteins there is a pressing need to produce recombinant proteins in secreted form. Trimeric soluble ENV GPs are also better immunogens for production of virus neutralising antibodies. Purpose of this review is to provide an overview of problems and potential solutions to the production of secreted trimeric viral ENV proteins for structural studies, clinical or diagnostic pu...

In vivo selection of novel biotherapeutics

There is an impelling demand to develop novel therapeutics against degenerative disorders. Approximately 30% of people over 80 years of age develop a dementia and 1-3% of those over 65 years have Parkinson’s disease. Over 17 million patients suffer from heart failure, mostly as a consequence of lack of cardiac regeneration after ischemic cardiomyocyte death. After 75 years of age, 30% of indivi...

Immunomodulatory Effects of Viral TLR