S148. DIFFERENTIAL NEURAL REWARD MECHANISMS IN TREATMENT RESPONSIVE AND TREATMENT RESISTANT SCHIZOPHRENIA
نویسندگان
چکیده
منابع مشابه
Is treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review
BACKGROUND Schizophrenia is a highly heterogeneous disorder, and around a third of patients are treatment-resistant. The only evidence-based treatment for these patients is clozapine, an atypical antipsychotic with relatively weak dopamine antagonism. It is plausible that varying degrees of response to antipsychotics reflect categorically distinct illness subtypes, which would have significant ...
متن کاملMagnetic resonance imaging and single photon emission tomography in treatment-responsive and treatment-resistant schizophrenia.
BACKGROUND Patients with schizophrenia differ from controls in several measures of brain structure and function, but it is uncertain how these relate to clinical features of the illness. We dichotomised patient groups by treatment response to test the hypothesis that treatment-resistant patients exhibit more marked biological abnormalities than treatment-responsive patients. METHOD Twenty tre...
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30 It has been estimated that a third of schizophrenia patients are treatment resistant 31 (TRS). Recent studies show that functional connectivity (FC) can be used for measuring 32 connections between brain regions in diseased states. White and colleagues used FC to 33 identify differences between schizophrenia patients responding to antipsychotic treatment 34 and TRS patients. Their results su...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2018
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sby018.935