S-adenosyl-L-methionine improves ventricular remodeling after myocardial infarction by regulating angiogenesis and fibrosis

Purpose: To investigate the effect of S-adenosyl-L-methionine (SAM) on angiogenesis and fibrosis in heart rats with myocardial infarction (MI), to determine mechanism action.Methods: Sprague Dawley MI received SAM treatment (15 mg/kg) intraperitoneally. The cumulative survival (%) was recorded their rate survival. Hematoxylin-eosin staining, echocardiography, hemodynamics were also performed. In addition, effects vascular regeneration analyzed by determining expression endothelial growth factor (VEGF), basic fibroblast (bFGF) hypoxia-inducible 1-α (HIF1-α) rats.Results: 8-week group significantly lower than that sham group, while improved rats. contractile diastolic function increased ventricular pressure change. Furthermore, elevated expressions VEGF, bFGF HIF1-α rat myocardium serum. tissues SAM-treated rats, collagen I, III α-sma reduced, indicating inhibited fibrosis. promoted cardiac activating Jagged1/Notch1 signaling pathway.Conclusion: promotes pathway inhibiting myocardium. Therefore, effectively inhibits remodeling after MI, thereby improving rats’ structure function. results may provide new targets for infarction.