rK39: A Cloned Antigen of Leishmania chagasi that Predicts Active Visceral Leishmaniasis
نویسندگان
چکیده
منابع مشابه
Comparative Study of rK39 Leishmania Antigen for Serodiagnosis of Visceral Leishmaniasis: Systematic Review with Meta-Analysis
BACKGROUND The rK39 recombinant protein is derived from a specific antigen produced by the Leishmania donovani complex, and has been used in the last two decades for the serodiagnosis of visceral leishmaniasis. We present here a systematic review and meta-analysis of studies evaluating serologic assays to diagnose visceral leishmaniasis to determine the accuracy of rK39 antigen in comparison to...
متن کاملMolecular characterization of a kinesin-related antigen of Leishmania chagasi that detects specific antibody in African and American visceral leishmaniasis.
We report the cloning of a Leishmania chagasi antigen gene and an evaluation of leishmaniasis patient antibody responses to the recombinant protein, rK39. rK39 contains a 39-amino acid repeat that is part of a 230-kDa protein predominant in L. chagasi tissue amastigotes. Sequence analyses showed this protein, LcKin, to be related to the kinesin superfamily of motor proteins. Southern blot analy...
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brigipulpis was abseni. In addition tu the laiicr sprcics, the authors corisidercd Lu. ezluilsi iu be B puiaiivr vrcior of VL in ihis lwiiliry. In Custa Rica, 2El.liUON el d. (I 984) also observed the association of Lu. cuutrsi wiih Lu. lorigipulp¡s i i i an endemic focus of the disease. ¡hing rxploraiory visi18 IO ihr aburiginal rcscrvr of Sari Andres de Soiavcnio (SAS), Dcparilnelit of Ctirdo...
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ژورنال
عنوان ژورنال: Journal of Infectious Diseases
سال: 1996
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/173.3.758