منابع مشابه
Resistance to HER2-targeted therapy
Production and approval of trastuzumab (Herceptin®) for the treatment of metastatic breast cancer (MBC) was a millstone in antibody-based targeted therapy in the cancer treatment. However, despite the early success in the clinical trials, trastuzumab failed to appreciate the initial attraction due to development of resistance to the drug. The majority of patients who benefit from the drug...
متن کاملABC of monitoring drug therapy. Theophylline.
It is not possible to establish a single dosage regimen for theophylline or its derivatives (for example, aminophylline) that will suit all patients because the metabolism of theophylline varies greatly from person to person. This variation is reflected in its elimination half life, which varies from four hours in healthy adult smokers to about 25 hours in patients with hepatic cirrhosis. Sever...
متن کاملresistance to her2-targeted therapy
production and approval of trastuzumab (herceptin®) for the treatment of metastatic breast cancer (mbc) was a millstone in antibody-based targeted therapy in the cancer treatment. however, despite the early success in the clinical trials, trastuzumab failed to appreciate the initial attraction due to development of resistance to the drug. the majority of patients who benefit from the drug acqui...
متن کاملSalmeterol plus theophylline combination therapy in the treatment of COPD.
BACKGROUND Patients with COPD often require multiple therapies to improve lung function and decrease symptoms and exacerbations. Salmeterol and theophylline are indicated for the treatment of COPD, but the use of these agents in combination has not been extensively studied. OBJECTIVES To compare the efficacy and safety of salmeterol plus theophylline vs either agent alone in COPD. METHODS R...
متن کاملNocturnal asthma: slow-release terbutaline versus slow-release theophylline therapy.
In a double-blind cross-over study, the effects of slow release (S-R) terbutaline tablets (b.i.d. 0.25 mg/kg per day) and S-R theophylline (5.31 mg/kg morning and 10.62 mg/kg evening) were compared in eleven patients with nocturnal asthma. On day seven of each treatment period, drug serum concentrations and peak expiratory flow (PEF) were measured every 2h over a 24-h period. During daytime, te...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.796.8