Resistance to -Lactam Antibiotics in Bacteroides Spp.

716Risk Factors for Resistance to Beta-lactam/Beta-lactamase Inhibitors and Carbapenems in Bacteroides spp. Bacteremia

and Carbapenems in Bacteroides spp. Bacteremia Janessa Smith, PharmD; Edina Avdic, MBA, PharmD, BCPS AQ-ID; Pranita D. Tamma, MD, MHS; Long Zhang, MHS; Sara Cosgrove, MD, MS, FIDSA, FSHEA; Department of Pharmacy, Johns Hopkins Hospital, Baltimore, MD; Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology...

Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against β-lactam antibiotics

OBJECTIVES To identify β-lactamase genes in gut commensal Bacteroides species and to assess the impact of these enzymes, when carried by outer membrane vesicles (OMVs), in protecting enteric pathogens and commensals. METHODS A deletion mutant of the putative class A β-lactamase gene (locus tag BT_4507) found in the genome of the human commensal Bacteroides thetaiotaomicron was constructed and...

Beta-lactam antibiotics: from antibiosis to resistance and bacteriology.

This review focuses on the era of antibiosis that led to a better understanding of bacterial morphology, in particular the cell wall component peptidoglycan. This is an effort to take readers on a tour de force from the concept of antibiosis, to the serendipity of antibiotics, evolution of beta-lactam development, and the molecular biology of antibiotic resistance. These areas of research have ...

Lactam Antibiotics

A novel endopeptidase degrading the pel)tide cross-links in sacculi has been isolated from Escherichia coli and purified to homogeneity. I'lhe enzyme has a molecular weight of 30,000 and, in contrast to already known enzymes of similar specificity, remains fully active in the presence of/3-lactam antibiotics. In adldition, it is exceptional in being inhibited by single-strandetl tleoxyribonucle...

-Lactam Antibiotics