Reply to “Packed Red Blood Cells Accumulate Oxidative Stress With Increased Storage Duration”
نویسندگان
چکیده
منابع مشابه
Temporal sequence of major biochemical events during blood bank storage of packed red blood cells.
BACKGROUND We used sensitive spectroscopic techniques to measure changes in Band 3 oligomeric state during storage of packed red blood cells (RBC); these changes were compared to metabolic changes, RBC morphology, cholesterol and membrane protein loss, phospholipid reorganisation of the RBC membrane, and peroxidation of membrane lipid. The aim of the study was to temporally sequence major bioch...
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BACKGROUND Exposure to high concentrations of oxygen radicals, the lack of nucleus and mitochrondria, inability to synthesise new protein and degradation of detoxifying enzymes makes red blood cells (RBCs) uniquely vulnerable to oxidative stress. This review summarizes the changes in biochemical parameters that primarily contribute to alterations in red blood cells during oxidative stress. ME...
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We studied the nature of enucleated RBCs containing DNA remnants, Howell-Jolly (HJ) RBCs and reticulocytes (retics), that are characteristically present in the circulation of thalassemic patients, especially after splenectomy. Using flow cytometry methodology, we measured oxidative status parameters of these cells in patients with β-thalassemia. In each patient studied, these cells had higher c...
متن کاملTowards microfluidic-based depletion of stiff and fragile human red cells that accumulate during blood storage.
In this study, the effects of prolonged storage on several biophysical properties of red blood cells (RBCs) were investigated. Single cell deformability was used as an important criterion in determining subgroups of RBCs evolved during storage lesion. A deformability-based microfluidic cell sorting technology was applied, which demonstrates the ability to enrich and separate the less deformable...
متن کاملRED CELLS Reduced oxidative-stress response in red blood cells from p45NFE2-deficient mice
p45NF-E2 is a member of the cap ‘n’ collar (CNC)-basic leucine zipper family of transcriptional activators that is expressed at high levels in various types of blood cells. Mice deficient in p45NF-E2 that were generated by gene targeting have high mortality from bleeding resulting from severe thrombocytopenia. Surviving p45nf-e22/2 adults have mild anemia characterized by hypochromic red blood ...
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ژورنال
عنوان ژورنال: Shock
سال: 2017
ISSN: 1073-2322
DOI: 10.1097/shk.0000000000000858