منابع مشابه
Wound healing--scar wars.
Scafring following wounding is a major medical problem. In skin wounds or bums scarring often leads to adverse cosmesis and consequent psychological problems, adverse function particularly over joints and retardation of growth especially in children. Scarring in muscle adversely affects movement and can cause ankylosis. In abdominal and pelvic organs scarring can lead to life threatening strict...
متن کاملHuman Wharton’s Jelly Mesenchymal Stem Cells Plasticity Augments Scar-Free Skin Wound Healing with Hair Growth
Human mesenchymal stem cells (MSCs) are a promising candidate for cell-based transplantation and regenerative medicine therapies. Thus in the present study Wharton's Jelly Mesenchymal Stem Cells (WJ-MSCs) have been derived from extra embryonic umbilical cord matrix following removal of both arteries and vein. Also, to overcome the clinical limitations posed by fetal bovine serum (FBS) supplemen...
متن کاملScar-free healing
Mending wounds quickly while keeping them scar-free is not an impossible task. Mori et al. (page 43) find that shutting down a protein called osteopontin does the trick. Scars form when the inflammatory response that protects skin wounds against invading microbes induces the release of chemokines, which recruit fibroblasts. These cells then generate swathes of collagen to provide a new matrix f...
متن کاملCalpain Activity Is Essential in Skin Wound Healing and Contributes to Scar Formation
Wound healing is a multistep phenomenon that relies on complex interactions between various cell types. Calpains are ubiquitously expressed proteases regulating several processes including cellular adhesion and motility as well as inflammation and angiogenesis. Calpains can be targeted by inhibitors, and their inhibition was shown to reduce organ damage in various disease models. We aimed to as...
متن کاملScar Prevention and Enhanced Wound Healing Induced by Polydeoxyribonucleotide in a Rat Incisional Wound-Healing Model
High-mobility group box protein-1 (HMGB-1) plays a central role in the inflammatory network, and uncontrolled chronic inflammation can lead to excessive scarring. The aim of this study was to evaluate the anti-inflammatory effects of polydeoxyribonucleotide (PDRN) on scar formation. Sprague-Dawley rats (n = 30) underwent dorsal excision of the skin, followed by skin repair. PDRN (8 mg/kg) was a...
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ژورنال
عنوان ژورنال: Tissue Engineering Part B: Reviews
سال: 2019
ISSN: 1937-3368,1937-3376
DOI: 10.1089/ten.teb.2018.0350