Recent Prospectives of Anticancer Histone Deacetylase Inhibitors
نویسندگان
چکیده
منابع مشابه
Hydroxamic Acid Based Histone Deacetylase Inhibitors: Present and Future Prospectives as Anticancer Agent
Histone deacetylases are set of enzymes that have been of interest in drug discovery for the last more than 3 decades. They are responsible for cleaving of acetyl groups from acetyl-lysine residues in histones and various non-histone proteins. Histone deacetylase inhibition is a contemporary, clinically validated therapeutic tactic for cancer treatment. Hydroxamic acid derivatives are among the...
متن کاملHistone deacetylase inhibitors as novel anticancer therapeutics
Histone deacetylase inhibitors represent a promising new class of compounds for the treatment of cancer. Inhibitors of this kind currently under clinical evaluation mainly target the classical (Rpd3/Hda1) family of histone deacetylases. Of particular note, the U.S. Food and Drug Administration recently approved the first histone deacetylase inhibitor (Zolinza: Merck and Co., Whitehouse Station,...
متن کاملHistone deacetylase inhibitors (HDACIs): multitargeted anticancer agents
Histone deacetylase (HDAC) inhibitors are an emerging class of therapeutics with potential as anticancer drugs. The rationale for developing HDAC inhibitors (and other chromatin-modifying agents) as anticancer therapies arose from the understanding that in addition to genetic mutations, epigenetic changes such as dysregulation of HDAC enzymes can alter phenotype and gene expression, disturb hom...
متن کاملHistone Deacetylase Inhibitors as Anticancer Drugs
Carcinogenesis cannot be explained only by genetic alterations, but also involves epigenetic processes. Modification of histones by acetylation plays a key role in epigenetic regulation of gene expression and is controlled by the balance between histone deacetylases (HDAC) and histone acetyltransferases (HAT). HDAC inhibitors induce cancer cell cycle arrest, differentiation and cell death, redu...
متن کاملInhibitors of histone deacetylase are potentially effective anticancer agents.
During the past decade, a number of HDAC inhibitors have been identified that induce tumor cells in culture and in tumor-bearing animals to undergo growth arrest, differentiation, and/or apoptotic cell death (1). Acetylation and deacetylation of histones, part of the core proteins of nucleosomes, play an important role in the regulation of gene expression (2). There are two classes of enzymes i...
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ژورنال
عنوان ژورنال: Journal of advanced Biomedical and Pharmaceutical Sciences
سال: 2019
ISSN: 2535-2040
DOI: 10.21608/jabps.2019.14468.1051