Recent progress in diagnosis and pathomechanism of inclusion body myositis
نویسندگان
چکیده
منابع مشابه
Inclusion body myositis – pathomechanism and lessons from genetics
Inclusion body myositis is a rare, late-onset myopathy. Both inflammatory and myodegenerative features play an important role in their pathogenesis. Overlapping clinicopathological entities are the familial inclusion body myopathies with or without dementia. These myopathies share several clinical and pathological features with the sporadic inflammatory disease. Therefore, better understanding ...
متن کاملInclusion body myositis pathogenesis: Steady progress.
Inclusion body myositis (IBM) is a slowly progressive skeletal muscle disease for which no effective pharmacological therapy is available. Since its initial pathological description 50 years ago, substantial progress has been made in our clinical understanding of IBM. We now have extensive understanding of its demographics, pattern of muscle involvement, and diagnostic criteria, and large amoun...
متن کاملInclusion body myositis: review of recent literature.
Inclusion body myositis (IBM) is a progressive inflammatory skeletal muscle disease of unknown cause and without effective treatment. This article discusses existing literature, emphasizing disease mechanisms and models. In particular, it addresses limitations in the beta-amyloid-mediated theory of IBM myofiber injury, flawed rationales of animal models of this disease, and recent reports regar...
متن کاملInclusion body myositis: advancements in diagnosis, pathomechanisms, and treatment.
PURPOSE OF REVIEW To review new advances in inclusion body myositis (IBM) and discuss them in light of current knowledge on diagnosis, pathomechanisms, and treatment perspectives. RECENT FINDINGS IBM is a treatment refractory inflammatory myopathy in middle-aged patients that leads to a slow, relentlessly progressive muscle weakness, and atrophy. Recent data collections suggest that mortality...
متن کاملDiagnosis and classification of sporadic inclusion body myositis (sIBM).
Sporadic inclusion body myositis (sIBM) is the most common acquired muscle disease in elderly individuals, particularly men. Its prevalence varies among ethnic groups but is estimated at 35 per one million people over 50. Genetic as well as environmental factors and autoimmune processes might both have a role in its pathogenesis. Unlike other inflammatory myopathies, sIBM causes very slowly pro...
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ژورنال
عنوان ژورنال: Rinsho Shinkeigaku
سال: 2014
ISSN: 0009-918X,1882-0654
DOI: 10.5692/clinicalneurol.54.1115