Raised serum immunoglobulin E in Wegener's granulomatosis.

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Raised serum immunoglobulin E in Wegener's granulomatosis.

Five patients with Wegner's granulomatosis were found to have significantly raised serum immunoglobulin E (IgE) levels. The rise in IgE was not related to the extent of clinical involvement, was not part of a generalized serum immunoglobulin rise, and was not associated with eosinophilia. Raised serum IgE may be a clue to the pathogenesis of this disease.

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ENT manifestations of Wegeners granulomatosis.

Wegeners granulomatosis is a necrotizing granulomatous vasculitis with multisystemic involvement. We present two cases of Wegener's presenting with otological manifestations as the first symptom. These symptoms are subtle and diagnosis may be easily overlooked. Hence a high index of suspicion is required. Early diagnosis and treatment goes a long way in improving the outcomes and in preventing ...

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Neutrophil chemotaxis in Wegeners granulomatosis and idiopathic pulmonary fibrosis

Background: The presence of anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener’s granulomatosis (WG), implicate the neutrophil as a key effector cell. Previous studies have reported elevated neutrophil counts in the lung although the determinants of neutrophil chemotaxis in the WG lung are unknown. Methods: BALF cell counts, myeloperoxidase (MPO) and chemokines were measured in 27 patient...

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 1976

ISSN: 0003-4967

DOI: 10.1136/ard.35.4.377