Quantifying why urea is a protein denaturant, whereas glycine betaine is a protein stabilizer
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چکیده
منابع مشابه
Quantifying why urea is a protein denaturant, whereas glycine betaine is a protein stabilizer.
To explain the large, opposite effects of urea and glycine betaine (GB) on stability of folded proteins and protein complexes, we quantify and interpret preferential interactions of urea with 45 model compounds displaying protein functional groups and compare with a previous analysis of GB. This information is needed to use urea as a probe of coupled folding in protein processes and to tune mol...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2011
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1109372108