Proton pump inhibitors and peptic ulcer management: Antioxidant mechanisms

Peptic ulcer (P.U.) is the gastrointestinal tract's most frequent disorder affecting mainly stomach and duodenum. Surgical intervention, ingested materials microbial infections may trigger inflammation that further predispose to oxidative stress. Proton pump inhibitors (PPIs) are group of compounds established for suppressions gastric acid secretions profoundly permanently over a reasonably long period time. Oxidative stress has been shown be involved in pathophysiology various diseases disorders, including P.U. Particularly when H. pylori infection accompanies it. In addition colonization this microorganism, mucosa subjected extreme with large levels inflammatory cell aggregation, which eventually disorder. PPIs exert several effects other than suppression can used treat Helicobacter infections, disorders respiratory tract, viral conditions related dysfunction endothelium by activating endogenous antioxidant protection reducing release cytokine. Recent therapeutic protocols have recommended as gastro-protective not only because their properties, but also potent anti-inflammatory properties.
 Keywords: Pump Inhibitors, Ulcer, Stress,