Proteinase-activated receptor pharmacology: trickier and trickier
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چکیده
منابع مشابه
AB061. Trickier and tips for surgical treatment of complex male urethral fistula
The male urethral fistula is the common and difficult complication of the surgical treatments of urethral stricture, hypospadias and prostate disease. Surgical reconstruction remains the mainstay in the management. Sometime the surgical therapy of the male urethral fistula is still a challenge. The key point of the treatment of anterior urethral fistula is using Dartos Fascia flap to overlappin...
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Proteinase-activated receptors (PARs) represent a unique subclass of G-protein-coupled receptors of which four family members have now been cloned from a number of species. The novel mechanism of receptor activation involves the proteolytic unmasking of a cryptic N-terminal receptor sequence that, remaining tethered, binds to and triggers receptor function. In addition, short (five to six amino...
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Recently, the role of serine proteinases in the pathogenesis of inflammation and autoimmune diseases via interaction with the proteinase-activated receptor (PAR) has attracted attention. Activation of PAR has a pro-inflammatory effect through the overproduction of inflammatory cytokines such as interleukin (IL)-6 and IL-8. PAR(2) activation in human esophageal epithelial cells by trypsin induce...
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Trypsin activates proteinase-activated receptor-2 (PAR(2)) by a mechanism that involves the release of a tethered receptor-activating sequence. We have identified two peptides, FSLLRY-NH(2) (FSY-NH(2)) and LSIGRL-NH(2) (LS-NH(2)) that block the ability of trypsin to activate PAR(2) either in PAR(2)-expressing Kirsten virus-transformed kidney (KNRK) cell lines or in a rat aorta ring preparation....
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2004
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0705949