Protein association changes in the Hedgehog signaling complex mediate differential signaling strength
نویسندگان
چکیده
منابع مشابه
Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling
Differentiated airway epithelia produce sonic hedgehog (SHH), which is found in the thin layer of liquid covering the airway surface. Although previous studies showed that vertebrate HH signaling requires primary cilia, as airway epithelia mature, the cells lose primary cilia and produce hundreds of motile cilia. Thus, whether airway epithelia have apical receptors for SHH has remained unknown....
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ژورنال
عنوان ژورنال: Development
سال: 2018
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.166850