Protective Ig responses

Polysaccharide-Specific Ig Isotype Responses to Streptococcus pneumoniae

Protective responses in the ischemic myocardium.

Acute coronary syndromes and heart failure arising as a consequence of ischemic injury to the myocardium account for a large proportion of all hospital admissions and of all causes of death in industrialized nations. Medical and surgical management of these conditions consumes enormous resources each year, but current therapeutic measures fall far short of reducing death and disability from isc...

Regulation of Protective and Pathogenic Th17 Responses

The recent description of a T helper lymphocyte subset (Th17) that is characterized by the production of IL-17, TNF, IL-6, IL-22, and GM-CSF has substantially influenced current concepts of the pathogenesis of inflammatory diseases such as arthritis or encephalitis. Contrasting with the prevailing dogma that held IFNproducing Th1 cells responsible for the pathogenesis of most organ-specific aut...

Purification of Ig-fusion proteins from medium containing Ig.

Fusion proteins are extremely useful for a wide range of experimental and clinical applications. In contrast to bacterial expression systems that have been used for cytoplasmic regions of proteins, many mammalian cell surface and secreted proteins have important features such as posttranslational modifications (e.g., glycosylation) that require expression in eukaryotic systems. Fusion proteins ...

Protective and pathologic immune responses in human tegumentary leishmaniasis

Studies in the recent years have advanced the knowledge of how host and parasite factors contribute to the pathogenesis of human tegumentary leishmaniasis. Polymorphism within populations of Leishmania from the same species has been documented; indicating that infection with different strains may lead to distinct clinical pictures and can also interfere in the response to treatment. Moreover, d...