Prostaglandin E2 Increase in Pachydermoperiostosis Without 15-hydroprostaglandin Dehydrogenase Mutations
نویسندگان
چکیده
منابع مشابه
P03-020 - A novel 15-HPGD mutation in pachydermoperiostosis
Introduction Autosomal recessive primary hypertrophic osteoathropathy (PHO), also known as pachydermoperiostosis (PDP), is a rare genetic disease characterized by clubbing of the fingers, arthritis, periostosis and pachydermia and results from mutations in 15-hydroxyprostaglandin dehydrogenase (HPGD). Recessive mutations in 15-hydroxyprostaglandin dehydrogenase in PHO subjects. has been identif...
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Elizabeth M. Poole, Li Hsu, Liren Xiao, Richard J. Kulmacz, Christopher S. Carlson, Peter S. Rabinovitch, Karen W. Makar, John D. Potter, Cornelia M. Ulrich 1 Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109 2 Department of Epidemiology, University of Washington, Seattle, Washington, 98195 3 Department of Internal Medicine, University of Texas Health Science Center at Houston,...
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The chondrogenic differentiation of synovial mesenchymal stem cells (SMSCs) is regulated by essential transcription factors and signaling cascades. However, the precise mechanisms involved in this process remain unclear. MicroRNAs (miRs/miRNAs) are undersized non‑coding RNAs responsible for the post‑transcriptional regulation of gene expression, by binding to the 3'‑untranslated regions (3'‑UTR...
متن کاملPioglitazone and rosiglitazone decrease prostaglandin E2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase.
Lung cancer cells elaborate the immunosuppressive and antiapoptotic mediator prostaglandin E(2) (PGE(2)), a product of cyclooxygenase-2 (COX-2) enzyme activity. Because peroxisome proliferator-activated receptor (PPAR)gamma ligands, such as thiazolidinediones (TZDs), inhibit lung cancer cell growth, we examined the effect of the TZDs pioglitazone and rosiglitazone on PGE(2) levels in non-small-...
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ژورنال
عنوان ژورنال: Acta Dermato Venereologica
سال: 2013
ISSN: 0001-5555
DOI: 10.2340/00015555-1398