PROPERTIES OF A PENICILLIN INACTIVATOR EXTRACTED FROM PENICILLIN-RESISTANT STAPHYLOCOCCI 1

Properties of a Penicillin Inactivator Extracted from Penicillin-resistant Staphylococci.

Some characteristics of penicillin-resistant staphylococci.

Penicillin-resistant and penicillin-tolerant mutants of group A Streptococci.

Penicillin-resistant and penicillin-tolerant mutants have been isolated from group A streptococci mutagenized by ethyl methane sulfonate. The resistant mutants had an elevated minimal growth inhibitory concentration for benzylpenicillin (minimal inhibitory concentration, 0.2 microgram/ml, as compared with the minimal inhibitory concentration of 0.006 microgram/ml in the penicillin-susceptible p...

Penicillin-resistant viridans streptococci have obtained altered penicillin-binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae.

Penicillin-resistant strains of Streptococcus pneumoniae possess altered forms of penicillin-binding proteins (PBPs) with decreased affinity for penicillin. The PBP2B genes of these strains have a mosaic structure, consisting of regions that are very similar to those in penicillin-sensitive strains, alternating with regions that are highly diverged. Penicillin-resistant strains of viridans grou...

Classification of staphylococci by penicillin lysis.

It has been recognized for some time that staphylococci may be divided into those which do and those which do not produce a penicillinase (Hobby & Dawson, 1944; Spink, Ferris & Vivino, 1944; Kirby, 1945a, b) . Also, staphylococci are often tested for their penicillin sensitivity (tolerance) and classified as ‘sensitive’ or ‘insensitive’. The literature contains a number of references to another...