Prolonged Infusions of Estradiol Dilate the Ovine Fetal Pulmonary Circulation
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چکیده
منابع مشابه
NO and prostaglandin interactions during hemodynamic stress in the fetal ovine pulmonary circulation.
Nitric oxide (NO) and prostacyclin (PGI(2)) are potent fetal pulmonary vasodilators, but their relative roles and interactions in the regulation of the perinatal pulmonary circulation are poorly understood. We compared the separate and combined effects of nitric oxide synthase (NOS) and cyclooxygenase (COX) inhibition during acute hemodynamic stress caused by brief mechanical compression of the...
متن کاملFetal and neonatal pulmonary circulation.
During fetal life, gas exchange is carried out in the placenta. The lung does not have a physiological role, apart from possible metabolic functions which include secretion of hormones, enzymatic conversion of inactive substances to functional hormones, and degradation of active materials to inactive metabolites. Blood flow through the lungs is quite low during fetal life; most of the systemic ...
متن کاملInhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation.
Mechanisms that maintain high pulmonary vascular resistance (PVR) and oppose vasodilation in the fetal lung are poorly understood. In fetal lambs, increased pulmonary artery pressure evokes a potent vasoconstriction, suggesting that a myogenic response contributes to high PVR in the fetus. In adult systemic circulations, the arachidonic acid metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) ...
متن کاملDoppler ultrasonography of the human fetal pulmonary circulation.
J.A.M. Laudy', M.A.J. de Ridder', J. W. Wladimiroff' Department of Obstetrics and Gynaecology, University Hospital Rotterdam, Institute of Epidemiology and Biostatisticsl, Erasmus UniverSity Medical School, Rotterdam, The Netherlands Published in: Pediatric Research 1.997;41:897-901 The objective of the present study was to determine the characteristics of Doppler flow velocity waveforms in bra...
متن کاملFasudil inhibits the myogenic response in the fetal pulmonary circulation.
In addition to high pulmonary vascular resistance (PVR) and low pulmonary blood flow, the fetal pulmonary circulation is characterized by mechanisms that oppose vasodilation. Past work suggests that high myogenic tone contributes to high PVR and may contribute to autoregulation of blood flow in the fetal lung. Rho-kinase (ROCK) can mediate the myogenic response in the adult systemic circulation...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2000
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-200001000-00017