Prognostic Value of Chromosome 1 Abnormalities in Myelodysplastic Syndrome

Chromosomal abnormalities in primary myelodysplastic syndrome.

OBJECTIVE To determine the frequency of cytogenetic abnormalities in patients diagnosed as primary myelodysplastic syndrome (MDS) using conventional karyotyping. STUDY DESIGN Case series. PLACE AND DURATION OF STUDY The Clinical Laboratory, The Aga Khan University Hospital, Karachi, between January 2006 - June 2012. METHODOLOGY Patients of all ages and either gender who fulfilled WHO crit...

Outcome of Myelodysplastic Syndrome (MDS) with and without Chromosome 5 Abnormalities

Comparison of Myelodysplastic Syndrome Prognostic Scoring Systems

OBJECTIVE Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disease. Patients are at risk of developing cytopenias or progression to acute myeloid leukemia. Different classifications and prognostic scoring systems have been developed. The aim of this study was to compare the different prognostic scoring systems. MATERIALS AND METHODS One hundred and one patients who were diag...

Myeloid Cell Leukemia-1 Gene Expression and Clinicopathological Features in Myelodysplastic Syndrome

Background and Aims: Myeloid cell leukemia-1 (Mcl-1) plays a pivotal role in the survival of hematologic and solid tumors, and is known as a substantial oncogene. Studies have demonstrated the altered expression of Mcl-1 has been linked to malignancy development and poor prognosis. In this research, we have studied the expression of Mcl-1 mRNA in myelodysplastic syndrome (MDS) patients and det...

Clinical effect of increasing doses of lenalidomide in high-risk myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities.

BACKGROUND Patients with chromosome 5 abnormalities and high-risk myelodysplastic syndromes or acute myeloid leukemia have a poor outcome. We hypothesized that increasing doses of lenalidomide may benefit this group of patients by inhibiting the tumor clone, as assessed by fluorescence in situ hybridization for del(5q31). DESIGN AND METHODS Twenty-eight patients at diagnosis or with relapsed ...