Prognosis after Surgery and/or Leuprolide Acetate Administration in Ferrets with Adrenal Diseases

Therapeutic Review Leuprolide Acetate

Leuprolide acetate is a potent Gonadotropin Releasing Hormone (GnRH) agonist. The general premise behind leuprolide is that it inhibits the synthesis of lutenizing hormone and follicle stimulating hormone via a negative feedback. By reducing the production of these hormones, the drug effectively reduces estrogen and androgen production. This compound has been formulated as a depot formulation (...

Ulipristal acetate versus leuprolide acetate for uterine fibroids.

BACKGROUND The efficacy and side-effect profile of ulipristal acetate as compared with those of leuprolide acetate for the treatment of symptomatic uterine fibroids before surgery are unclear. METHODS In this double-blind noninferiority trial, we randomly assigned 307 patients with symptomatic fibroids and excessive uterine bleeding to receive 3 months of daily therapy with oral ulipristal ac...

[Nicolau syndrome after administration of glatiramer acetate].

Local complications associated with glatiramer acetate are frequent, especially at the injection site. The presence of pain, oedema, and local erythema is almost a given in areas where the drug is administered subcutaneously. However, the presence of cutaneous necrosis should alert doctors to the possibility of impairment of underlying vascular structures. Nicolau syndrome or embolia cutis medi...

Adrenal insufficiency after glucocorticoid withdrawal in children with rheumatic diseases.

AIM  Glucocorticoids (GCs) are often used for the treatment of rheumatic disorders. However, doses are prescribed, which may suppress the hypothalamic-pituitary-adrenal (HPA) axis. After GC withdrawal, recovery of the HPA axis may be delayed putting the patient at risk for adrenal insufficiency. We assessed adrenal function and factors influencing adrenal responsiveness after termination of GC ...

Re: Intense Androgen-Deprivation Therapy with Abiraterone Acetate plus Leuprolide Acetate in Patients with Localized High-Risk