Probing the Aglycon Promiscuity of an Engineered Glycosyltransferase
نویسندگان
چکیده
منابع مشابه
Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution.
Natural products, many of which are decorated with essential sugar residues, continue to serve as a key platform for drug development. Adding or changing sugars attached to such natural products can improve the parent compound's pharmacological properties, specificity at multiple levels, and/or even the molecular mechanism of action. Though some natural-product glycosyltransferases (GTs) are su...
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چکیده ندارد.
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Diverse organophosphate hydrolases have convergently evolved the ability to hydrolyse man-made organophosphates. Thus, these enzymes are attractive model systems for studying the factors shaping enzyme functional evolution. Methyl parathion hydrolase (MPH) is an enzyme from the metallo-β-lactamase superfamily, which hydrolyses a wide range of organophosphate, aryl ester and lactone substrates. ...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2008
ISSN: 1433-7851,1521-3773
DOI: 10.1002/anie.200803508