Primary Nodal Merkel Cell Carcinoma: Rare Presentation

An Unusual Presentation of Merkel Cell Carcinoma

Merkel cell carcinoma (MCC) is an uncommon primary cutaneous neoplasm of neuroendocrine cells with a predilection for the head and neck and distal extremities in elderly patients. It is principally a disease of the Caucasian race with an incidence of 0.44 per 100,000 and is very high (8%) among immunsuppressed patients (1, 2). The disease course is difficult to predict and ranges from relativel...

Primary Cutaneous Neuroendocrine Carcinoma , Merkel Cell Carcinoma .

Merkel cell carcinoma and multiple primary cancers.

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumor of the skin for which causative factors remain largely unknown. The site-specific risks of multiple primary cancers associated with MCC, which may provide insight into etiologic influences, have not been quantified in large population-based studies. We estimated the long-term risk of subsequent primary tumors after a first primar...

Sustained remission of a primary nodal Merkel cell carcinoma in an HIV-positive patient.

scan of the chest and abdomen did not show any pathological lesions at other sites. Wide surgical resection of the tumor with inguinal lymph node excision was performed, and the pathological examination with immunohistochemical studies (positive cytokeratin 20, neuron-specific enolase and synaptophysin staining; negative cytokeratin 7 and thyroidtranscription factor-1 staining) led to a confirm...

Radiotherapy alone for primary Merkel cell carcinoma.

BACKGROUND Merkel cell carcinoma is a rare and potentially aggressive cancer of the skin. Cumulative data from small retrospective series have supported treatment by wide excision and adjuvant radiotherapy. However, wide excision may be difficult to perform in patients with tumors of the head and neck or in older populations with comorbidities that may be incompatible with general anesthesia. ...