Previous and potential mutations of Sars-cov-2 receptors and their interaction with known inhibitors

SARS-CoV-2, the seventh coronavirus known to infect humans after 229E, NL63, 0C43, HKU1, MERS-CoV, and original SARS-CoV, has a large positive-stranded RNA genome of 29,891 nucleotides 9,860 amino acids. It is strain that causes COVID 19. was first discovered in Chinese city Wuhan. undergoes several mutations hence posing great difficulty finding suitable inhibitor. This studies previous potential Sars-cov-2 receptors their interaction with inhibitors. There are four measures take generating SARS-CoV-2 inhibitors might surpass mutation should it arise which includes; a. two or more mechanism inhibition virus target b. employing host c. complex forming compounds will interfere viral-host cell fusion independent organism d. human receptor lookalikes higher affinity (proteins). Employing any these produce good inhibitor however, drug resistance may emerge quickly treatment as result numerous experience but uncommon, treatments cells delay emergence resistance.