Presence of CAT genetic markers as an indicator of accelerated rate of liver fibrosis progression in patients with chronic hepatitis

Goal. To evaluate the genetic profi le of patients with chronic hepatitis C (CHC) by CAT gene polymorphism in region-262G/A (rs1001179), GPX4 region-718C/T (rs713041), IL28B region C/T (rs12979860) and VEGFA region- 634G/C (rs2010963) to analyze association rate progression liver fi brosis polymorphic markers. Materials methods. We examined 36 CHC a rapidly progressive (up 10 years) 56 slowly course disease (more than years). The study single- nucleotide polymorphisms genes was carried out method polymerase chain reaction. Results. In group rapid brosis, individuals multiple risk alleles for studied were more common, which confi rms markers (rs1001179) (rs713041) their combined carrier. Among greater number had simultaneously 4–6 27.5%, while slow process only 11% cases. Conclusion. This set can be used as testing fibrosis determine prognosis disease.