Preparasi dan Karakterisasi Sistem Pembawa Liposom dari Ekstrak Etanol Daun Miana (Coleus atropurpureus L. Benth)

Miana (Coleus atropurpureus L. Benth) is a plant in the ornamental group that has benefits for body. The part of efficacious as medicine on leaves with brownish red color. However, extracts from miana are hydrophilic, making it difficult to penetrate biological membranes which rich lipids and use topically. One way overcome this problem by liposome carrier systems. Liposomes systems consisting phospholipids cholesterol ability encapsulate hydrophilic hydrophobic compounds. Parameters success formula include vesicle shape, high adsorption efficiency size using particle analyzer (PSA). was obtained through thin layer hydration method phosphatidylcholine cholesterol. composition optimum leaf ethanol extract 0.2% 0.4% complex spherical structure, entrapment 92.91%, 573.6 nm polydispersity index 0,505.