Potential Hexokinase II Inhibition by Benzimidazole Anthelmintics: Albendazole, Mebendazole and Fenbendazole
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منابع مشابه
Global deworming: moving past albendazole and mebendazole.
Since the 2001 adoption of the World Health Assembly (WHA) resolution calling for the global deworming of children affected by soil-transmitted helminth (STH) infections and schistosomiasis, the world’s public health leaders have gradually responded. Although we are still behind schedule in terms of the WHA’s original 2010 targets, WHO continues to report progress— in 2015, approximately 59% of...
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Various anthelmintics belonging to the pharmacolog~cal group of benzimidazoles (oxibendazole, thiabendazole, albendazole, oxfendazole, flubendazole, mebendazole, parbendazole, fenbendazole and triclabendazole) were tested and compared for their In vitro and in vivo activity against an infection of rainbow trout Onchorhynchus myhss by Gyrodactylus. The trout were also observed for signs of toxic...
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A simple and rapid liquid chromatographic method was developed for the simultaneous determination of twelve benzimidazole anthelmintics in livestock foods using reversed-phase high-performance liquid chromatography with photodiode array detection (PDA). A sample was homogenized with acetonitrile and n-hexane, and centrifuged. The acetonitrile phase was isolated and evaporated. The residue was d...
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Benzimidazole anthelmintics have reported anti-neoplastic effects both in vitro and in vivo. The purpose of this study was to evaluate the in vitro chemosensitivity of three canine glioma cell lines to mebendazole and fenbendazole. The mean inhibitory concentration (IC50 ) (±SD) obtained from performing the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay after treating ...
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The benzimidazole anthelmintics mebendazole and fenbendazole have been shown to be much less effective against Nippostrongylus brasiliensis infections in the rat on a combined iron and protein deficient diet. In the present experiments it was shown that the anthelmintic efficacy of mebendazole was significantly impaired in the rat on either an iron deficient or a protein deficient diet. Further...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Research International
سال: 2021
ISSN: 2456-9119
DOI: 10.9734/jpri/2020/v32i4631105